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位置: 首页 > 磷酸化抗体 > GTPase Activating Protein (Phospho-Ser387) Antibody

GTPase Activating Protein (Phospho-Ser387) Antibody#11983

GTPase Activating Protein (Phospho-Ser387) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称GTPase Activating Protein (Phospho-Ser387) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms

特异性The antibody detects endogenous level of GTPase Activating Protein only when phosphorylated at serine 387.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 387 (R-I-S(p)-G-C) derived from Human GTPase Activating Protein.

基因/蛋白名称GTPase Activating Protein

修饰Phospho

别名GTPase activating protein; GTPase activating protein ID-GAP; RAC GTPase- activating protein 1; RACGAP1; RAC GTPase-activating protein

数据库入口号Swiss-Prot#: Q9H0H5;
NCBI Gene#: 29127;
NCBI Protein#: NP_001119575.1

UniprotQ9H0H5

实际分子量72kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Western blotting: 1:500~1:1000
Western blot analysis of extracts from COS7 tissue using GTPase Activating Protein antibody #11983.The lane on the right is treated with the antigen-specific peptide.
背景

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation.

Doki N, et al. (2009)Cancer Sci 100, 1675-9. Minoshima Y, et al. (2003)Dev Cell 4, 549-60.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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