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位置: 首页 > 抗体 > MSK1(Ab-376) Antibody

MSK1(Ab-376) Antibody#21198

MSK1(Ab-376) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称MSK1(Ab-376) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu

特异性The antibody detects endogenous level of total MSK1 protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1.

基因/蛋白名称MSK1

别名MSPK1; RPS6KA5;

数据库入口号Swiss-Prot: O75582
NCBI Protein: NP_004746.2

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 90kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from HUVEC cells using MSK1(Ab-376) Antibody #21198 and the same antibody preincubated with blocking peptide.
背景
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68(2): 320-344
McCOY C, et al. (2005) Biochem J. Apr 15; 387(Pt 2): 507-517

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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025-58868422

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