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位置: 首页 > 磷酸化抗体 > Caveolin 2 (Phospho-Tyr27) Antibody

Caveolin 2 (Phospho-Tyr27) Antibody#11778

Caveolin 2 (Phospho-Tyr27) Antibody
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产品总价:
产品详情

产品名称Caveolin 2 (Phospho-Tyr27) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu

特异性The antibody detects endogenous levels of Caveolin 2 only when phosphorylated at tyrosine 27.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 27 (L-E-Y(p)-A-D) derived from Human Caveolin 2.

基因/蛋白名称Caveolin 2

修饰Phospho

别名CAV2; Caveolin-2;

数据库入口号Swiss-Prot#: P51636;
NCBI Gene#: 858;
NCBI Protein#: NP_001224.1.

UniprotP51636

实际分子量26kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Western blotting: 1:500~1:1000

Western blot analysis of extracts from cos-7 cells (Lane 2), using Caveolin 2 (Phospho-Tyr27) Antibody #11778. The lane on the left is treated with antigen-specific peptide.
背景

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.

Scherer P.E., Proc. Natl. Acad. Sci. U.S.A. 93:131-135(1996).
Scherer P.E., J. Biol. Chem. 272:29337-29346(1997).
Engelman J.A., FEBS Lett. 448:221-230(1999).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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