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位置: 首页 > 磷酸化抗体 > GRIN2B (Phospho-Ser1303) Antibody

GRIN2B (Phospho-Ser1303) Antibody#11821

GRIN2B (Phospho-Ser1303) Antibody
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产品总价:
产品详情

产品名称GRIN2B (Phospho-Ser1303) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous levels of GRIN2B only when phosphorylated at serine 1303.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of Serine 1303(Q-H-S(p)-Y-D) derived from Human GRIN2B.

基因/蛋白名称GRIN2B

修饰Phospho

别名GRIN2B; NMDE2; NME2; NR2B; NR3

数据库入口号Swiss-Prot#: Q13224;
NCBI Gene#: 2904;
NCBI Protein#: NP_000825.2.

UniprotQ13224

实际分子量170kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Western blotting: 1:500~1:1000

Western blot analysis of extracts from Mouse brain cells using GRIN2B (Phospho-Ser1303) Antibody #11821.The lane on the right is treated with the antigen-specific peptide.
背景

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

Adams S.L., Biochim. Biophys. Acta 1260:105-108(1995).
Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816(1996).
Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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