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位置: 首页 > 磷酸化抗体 > DRP1 (Phospho-Ser637) Antibody

DRP1 (Phospho-Ser637) Antibody#11842

DRP1 (Phospho-Ser637) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称DRP1 (Phospho-Ser637) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB,IHC,IF,ELISA

种属反应性Hu Rt Ms

特异性The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of Serine637(K-L-S(p)-A-R) derived from Human DRP1.

基因/蛋白名称DRP1

修饰Phospho

别名DLP1; DNM1L; DRP1; DVLP; Dymple

数据库入口号Swiss-Prot#: O00429;
NCBI Gene#: 10059;
NCBI Protein#: NP_036192.2.

UniprotO00429

实际分子量82kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Western blotting: 1:500~1:1000

Western blot analysis of extracts from JK cells and K562 cells using DRP1 (Phospho-Ser637) Antibody #11842.The lane on the right is treated with the antigen-specific peptide.
背景

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.

Shin H.-W., J. Biochem. 122:525-530(1997).
Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703(1998).
Imoto M., J. Cell Sci. 111:1341-1349(1998).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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