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位置: 首页 > 抗体 > SPHK1 Antibody

SPHK1 Antibody#32004

SPHK1 Antibody
SPHK1 Antibody
SPHK1 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称SPHK1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were purified by affinity purification using immunogen.

应用WB,IHC

种属反应性Human,Mouse,Rat

特异性The antibody detects endogenous level of total SPHK1 protein.

免疫原类型Recombinant Protein

免疫原描述Recombinant protein of human SPHK1 .

基因/蛋白名称SPHK1

别名PHK1; SPHK;

数据库入口号Swiss-Prot:Q9NYA1
NCBI Gene ID:8877

UniprotQ9NYA1

实际分子量43KD

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Western blot analysis of extracts of various cell lines, using SPHK1 antibody at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded human gastric cancer using SPHK1 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat liver using SPHK1 antibody at dilution of 1:100 (40x lens).
背景

Sphingosine kinases (SPHKs) catalyze the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Together with other sphingolipid metobolizing enzymes, SPHKs regulate the balance of the lipid mediators, ceramide, sphingosine, and S1P (1-4). Two distinct SPHK isoforms, SPHK1 and SPHK2, have been cloned and characterized (5,6). SPHK1 and SPHK2 are highly conserved and diverselly expressed (7,8). The SPHKs are activated by G-protein-coupled receptors, receptor tyrosine kinases, immunoglobulin receptors, cytokines, and other stimuli (9-12). The molecular mechanisms by which SPHK1 and SPHK2 are specifically regulated are complex and only partially understood.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

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Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com