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CDK4 Antibody#32073

CDK4 Antibody
CDK4 Antibody
CDK4 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CDK4 Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC

种属反应性Human,Mouse,Rat

特异性The antibody detects endogenous level of total CDK4 protein.

免疫原类型Peptide

免疫原描述Recombinant fusion protein of human CDK4 (NP_000066.1).

基因/蛋白名称CDK4

别名CDK4;CMM3;PSK-J3

数据库入口号Uniprot:P11802
GeneID:1019

UniprotP11802

Gene ID1019

实际分子量34kDa

浓度1.0mg/ml

配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using CDK4 antibody.
Western blot analysis of extracts of various cell lines, using CDK4 antibody.
Immunohistochemistry of paraffin-embedded human colon using CDK4 antibody.
背景
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

如果您使用该产品32073发表了文章,请通知我们,让我们可以引用您的文献。

et al,CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways. In Cancers (Basel) on 2022 Nov 15 by Xiyang Tan, Jie Yang, et al..PMID:36428703, , (2022),
PMID: 36428703
et al,Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27. In Cell Cycle on 2021 Dec 16 by Katia Coulonval, Vincent Vercruysse,et al..PMID:34913830, , (2021),
PMID: 34913830
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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