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TRAF2 Antibody#32094

TRAF2 Antibody
TRAF2 Antibody
TRAF2 Antibody
TRAF2 Antibody
TRAF2 Antibody
是否有货: 货期一周
产品总价:
产品详情

产品名称TRAF2 Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC

种属反应性Human,Mouse,Rat

特异性The antibody detects endogenous level of total TRAF2 protein.

免疫原类型Recombinant Protein

免疫原描述Recombinant fusion protein of human TRAF2 (NP_066961.2).

基因/蛋白名称TRAF2

别名MGC:45012;TRAP;TRAP3;TRAF2

数据库入口号Uniprot:Q12933
GeneID:7186

UniprotQ12933

Gene ID7186

实际分子量54kDa

浓度1.0mg/ml

配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using TRAF2 antibody.
Immunohistochemistry of paraffin-embedded mouse brain using [KO Validated] TRAF2 Rabbit pAb.
Immunohistochemistry of paraffin-embedded mouse spleen using [KO Validated] TRAF2 Rabbit pAb.
Immunohistochemistry of paraffin-embedded rat spleen using [KO Validated] TRAF2 Rabbit pAb.
Immunohistochemistry of paraffin-embedded rat testis using [KO Validated] TRAF2 Rabbit pAb.
背景
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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