产品详情
产品名称MMP3 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human,Mouse,Rat
特异性The antibody detects endogenous level of total MMP3 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human MMP3 (NP_002413.1).
基因/蛋白名称MMP3
别名MMP3;CHDS6;MMP-3;SL-1;STMY;STMY1;STR1
数据库入口号Uniprot:P08254
GeneID:4314
UniprotP08254
Gene ID4314
实际分子量60KDa/47KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using MMP3 antibody.
Western blot analysis of extracts of Rat liver, using MMP3 antibody.
Immunohistochemistry of paraffin-embedded human breast cancer using MMP3 Rabbit pAb.
Immunofluorescence analysis of C6 cells using MMP3 Polyclonal Antibody.
Immunofluorescence analysis of U-2 OS cells using MMP3 Polyclonal Antibody.
背景
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
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