免费电话:400-9961-933
邮箱:techcn@signalwayantibody.com
欢迎光临本站
登录 注册 English
位置: 首页 > 标记抗体 > HER2 receptor Mouse Monoclonal Antibody HRP Conjugated(1A4)

HER2 receptor Mouse Monoclonal Antibody HRP Conjugated(1A4)#C08424H

是否有货: 货期15天
产品总价:
产品详情

产品名称HER2 receptor Mouse Monoclonal Antibody HRP Conjugated(1A4)

来源种属Mouse

克隆性Monoclonal

克隆号1A4

亚型IgG

纯化Purified by Protein G.

应用WB IHC-P IHC-F

种属反应性WB IHC-P IHC-F

免疫原描述KLH conjugated synthetic peptide aa 155-205 1255 derived from human HER2 receptor

标记HRP

激发/发射波长N A

基因/蛋白名称HER2 receptor

别名NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2 neu; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; ERBB2; MLN19

数据库入口号Swiss-Prot#P04626
NCBI Gene ID2064

细胞定位Extracellular

浓度1mg ml

配方0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存Shipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.

应用详情
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200
背景
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2 COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

如果您使用该产品C08424H发表了文章,请通知我们,让我们可以引用您的文献。

5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

Location :

南京市高新开发区星火路10号人才大厦C座

Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com