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CD274 Antibody#32363

CD274 Antibody
CD274 Antibody
CD274 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CD274 Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC,IF

种属反应性Human,Mouse,Rat

特异性The antibody detects endogenous level of total CD274 protein.

免疫原类型Recombinant Protein

免疫原描述Recombinant fusion protein of human PD-L1/CD274 (NP_054862.1).

基因/蛋白名称CD274

别名B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274

数据库入口号Uniprot:Q9NZQ7
GeneID:29126

UniprotQ9NZQ7

Gene ID29126

实际分子量40-50KDa

浓度1.0mg/ml

配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using PD-L1/CD274 antibody.
Immunohistochemistry of paraffin-embedded Mouse testis using PD-L1/CD274 antibody.
Immunofluorescence analysis of RAW264.7 cells using PD-L1/CD274 antibody.
背景
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

如果您使用该产品32363发表了文章,请通知我们,让我们可以引用您的文献。

et al,CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways. In Cancers (Basel) on 2022 Nov 15 by Xiyang Tan, Jie Yang, et al..PMID:36428703, , (2022),
PMID: 36428703
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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