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位置: 首页 > 抗体 > Integrin b3(Ab-785) Antibody

Integrin b3(Ab-785) Antibody#21274

Integrin b3(Ab-785) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Integrin b3(Ab-785) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of total Integrin b3 protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.

基因/蛋白名称Integrin b3

别名CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa

数据库入口号Swiss-Prot: P05106
NCBI Protein: NP_000203.2

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 110kd
Western blotting: 1:500~1:1000

Western blot analysis of extracts from HL60 and HT29 cells using Integrin b3(Ab-785) Antibody #21274.
背景

The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit

Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437

如果您使用该产品21274发表了文章,请通知我们,让我们可以引用您的文献。

Ruifei Wang, Jiajia Bi, Khamal Kwesi Ampah et al,Lipid raft regulates the initial spreading of melanoma A375 cells bymodulating 1 integrin clustering., The International Journal of Biochemistry & Cell Biology., 45(8):1679-1689 (2013),
PMID: 23665237
et al,Lipid raft regulates the initial spreading of melanoma A375 cells by modulating 尾1 integrin clustering. In Int J Biochem Cell Biol on 2013 Aug by Ruifei Wang, Jiajia Bi,et al..PMID: 23665237, , (2013),
PMID: 23665237
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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