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NR3C1 Antibody#32634

NR3C1 Antibody
NR3C1 Antibody
NR3C1 Antibody
NR3C1 Antibody
NR3C1 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称NR3C1 Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC,IF

种属反应性Human,Mouse,Rat

特异性The antibody detects endogenous level of total NR3C1 protein.

免疫原类型Recombinant Protein

免疫原描述Recombinant fusion protein of human Glucocorticoid Receptor (NP_001191194.1).

基因/蛋白名称NR3C1

别名GCCR;GCR;GCRST;GR;GRL;NR3C1

数据库入口号Uniprot:P04150
GeneID:2908

UniprotP04150

Gene ID2908

实际分子量105kDa

浓度1.0mg/ml

配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using Glucocorticoid Receptor antibody.
Immunohistochemistry of paraffin-embedded rat spleen using Glucocorticoid Receptor Rabbit pAb.
Immunohistochemistry of paraffin-embedded human liver cancer using Glucocorticoid Receptor Rabbit pAb.
Immunofluorescence analysis of NIH/3T3 cells using Glucocorticoid Receptor Rabbit pAb.
Immunofluorescence analysis of PC-12 cells using Glucocorticoid Receptor Rabbit pAb.
背景
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

如果您使用该产品32634发表了文章,请通知我们,让我们可以引用您的文献。

et al,Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes. In Front Behav Neurosci on 2022 Aug 5 by Molly H Kent, Joanna C Jacob, et al..PMID: 35990727, , (2022),
PMID: 35990727
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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