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位置: 首页 > Akt信号通路 > GSK3α/β(Ab-279/216) Antibody

GSK3α/β(Ab-279/216) Antibody#21301

GSK3α/β(Ab-279/216) Antibody
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产品总价:
产品详情

产品名称GSK3α/β(Ab-279/216) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of total GSK3α/β protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.277~281/214~218 (V-S-Y-I-C) derived from Human GSK3α/β.

基因/蛋白名称GSK3α/β

别名Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta

数据库入口号Swiss-Prot: P49840/P49841
NCBI Protein: NP_063937.2/NP_001139628.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 46, 51kd
Western blotting: 1:500~1:1000

Western blot analysis of extracts from HL60, HT29 and 293 cells using GSK3α/β(Ab-279/216) Antibody #21301.
背景

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201
Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415
Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436
Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222

如果您使用该产品21301发表了文章,请通知我们,让我们可以引用您的文献。

et al,Cleavage of GSK-3尾 by Calpain Counteracts the Inhibitory Effect of Ser9 Phosphorylation on GSK-3尾 Activity Induced by H鈧侽锟?In J Neurochem on 2013 Jul by Ye Feng, Yiyuan Xia,et al..PMID:23646926, , (2013),
PMID: 23646926
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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