产品详情
产品名称CRY1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity purification
应用WB,IHC,ELISA
种属反应性Ms
特异性The antibody detects endogenous level of total CRY1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human CRY1 (NP_004066.1).
基因/蛋白名称CRY1
别名PHLL1
数据库入口号Swiss-Prot: Q16526
NCBI Protein: NP_031797.1
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 66kd
Western blotting: 1:500~1:2000
背景
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL
Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.
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