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位置: 首页 > 抗体 > LAT (Ab-255) Antibody

LAT (Ab-255) Antibody#33313

LAT (Ab-255) Antibody
LAT (Ab-255) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称LAT (Ab-255) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

应用WB,IHC,ELISA

种属反应性Hu,Ms,Rat

特异性The antibody detects endogenous levels of total LAT protein.

免疫原类型Peptide

免疫原描述Synthesized non-phosphopeptide derived from human LAT around the phosphorylation site of tyrosine 255.

基因/蛋白名称LAT

别名36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; LAT; LAT1; linker for activation of T cells

数据库入口号Swiss-Prot: O43561
NCBI Gene ID: 27040

UniprotO43561

实际分子量27kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情

WB 1:500-2000;
IHC 1:50-300;
ELISA 2000-20000

Western blot analysis of extracts from 293 cells, using LAT (Ab-255) antibody #33313.
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung.
背景

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Zhang W., Cell 92:83-92(1998).
Martin J., Nature 432:988-994(2004).

如果您使用该产品33313发表了文章,请通知我们,让我们可以引用您的文献。

5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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