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位置: 首页 > 磷酸化抗体 > IRS-1(Phospho-Ser312) Antibody

IRS-1(Phospho-Ser312) Antibody#11143

IRS-1(Phospho-Ser312) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称IRS-1(Phospho-Ser312) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 312.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 312 (A-T-S(p)-P-A) derived from Human IRS-1.

基因/蛋白名称IRS-1

修饰Phospho

别名HIRS-1; IRS1; Insulin receptor substrate 1

数据库入口号Swiss-Prot: P35568
NCBI Protein: NP_005535.1

UniprotP35568

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 180kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from 293 cells untreated or treated with insulin using IRS-1(Phospho-Ser312) antibody #11143.
背景
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5): 2355-2360
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645

如果您使用该产品11143发表了文章,请通知我们,让我们可以引用您的文献。

et al,Liraglutide Ameliorates HyperhomocysteInemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular TargetIng. In Neurosci Bull on 2019 Jan 10 by Zhang Y, Xie JZ, et al..PMID: 30632006, , (2019),
PMID: 30632006
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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