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位置: 首页 > Akt信号通路 > FAK(Ab-397) Antibody

FAK(Ab-397) Antibody#21208

FAK(Ab-397) Antibody
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产品总价:
产品详情

产品名称FAK(Ab-397) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous levels of total FAK protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa. 395~399 (D-D-Y-A-E) derived from Human FAK.

基因/蛋白名称FAK

别名FADK; PTK2; FAK1; FRNK; PTK2

数据库入口号Swiss-Prot: Q05397
NCBI Protein: NP_005598.3

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 125kd
Western blotting: 1:500~1:1000

Western blot analysis of extract from HepG2, 293, C6, HUVEC and HT29 cells using FAK(Ab-397) Antibody #21208
背景

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.

von Sengbusch A, et al. (2005) Am J Pathol ; 166(2): 585-596
Fornaro M, et al. (2000) Mol Biol Cell ; 11(7): 2235-2249
Zhang X, et al. (1999) Proc Natl Acad Sci U S A; 96(16): 9021-9026.

如果您使用该产品21208发表了文章,请通知我们,让我们可以引用您的文献。

et al,Long non-codIng RNA PVT1 promotes tumor progression by regulatIng the miR-143/HK2 axis In gallbladder cancer.In Mol Cancer on 2019 Mar 2 by Chen J, Yu Y, et al.. PMID: 30825877, , (2019),
PMID: 30931957
et al,Luteolin reduces the invasive potential of malignant melanoma cells by targeting 尾3 integrin and the epithelial-mesenchymal transition.In Acta Pharmacol Sin on 2012 Oct by Ruan JS, Liu YP,et al..PMID:22983392, , (2012),
PMID: 22983392
et al,Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells. In Mol Med Rep on 2012 Jul by Junshan Ruan, Lei Zhang, et al..PMID: 22552526, , (2012),
PMID: 22552526
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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