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位置: 首页 > 抗体 > E-Cadherin(CD324) Antibody

E-Cadherin(CD324) Antibody#21473

E-Cadherin(CD324) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称E-Cadherin(CD324) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of total E-Cadherin protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.

基因/蛋白名称E-Cadherin(CD324)

别名CDH1; CDHE; UVO

数据库入口号Swiss-Prot: P12830
NCBI Protein: NP_004351.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 135kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from MCF-7 and HT29 cells using E-Cadherin(CD324) Antibody #21473
背景
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386
Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010
Agiostratidou G. (2006)J. Neurochem. 96:1182-1188

如果您使用该产品21473发表了文章,请通知我们,让我们可以引用您的文献。

et al,N鈥憁ethyl鈥慛鈥憂itro鈥慛'鈥憂itrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2鈥憁ediated migration.In Mol Med Rep On 2016 Feb by Jie Cai , Mei Wang et al..PMID:26648448, , (2016),
PMID: 26648448
et al,Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher. In J Agric Food Chem on 2016 Aug 17 by Min Guo, Guo-Bin Ding,et al..PMID: 27465400, , (2016),
PMID: 27465400
et al, Octamer-binding protein 4 affects the cell biology and phenotypic transition of lung cancer cells involving 尾-catenin/E-cadherin complex degradation.In Mol Med Rep on 2015 Mar by Zhong-Shu Chen, Dong-Jin Ling et al..PMID: 25420671 , , (2015),
PMID: 25420671
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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