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位置: 首页 > 磷酸化抗体 > STAT5a(Phospho-Tyr694) Antibody

STAT5a(Phospho-Tyr694) Antibody#11048

STAT5a(Phospho-Tyr694) Antibody
STAT5a(Phospho-Tyr694) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称STAT5a(Phospho-Tyr694) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB IHC

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of STAT5A only when phosphorylated at tyrosine 694.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 694 (D-G-Y(p)-V-K) derived from Human STAT5A.

基因/蛋白名称STAT5a

修饰Phospho

别名MGF; MPF; Mammary gland factor; STA5A,; STAT5

数据库入口号Swiss-Prot: P42229
NCBI Protein: NP_003143.2

UniprotP42229

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 90kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from K562 cells untreated or treated with G-CSF using STAT5A(Phospho-Tyr694) Antibody #11048.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT5A(Phospho-Tyr694) Antibody #11048(left) or the same antibody preincubated with blocking peptide(right).
背景
Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Gouilleux F, et al. (1994) EMBO J. 13: 4361-4369.
Dentelli P, et al. (1999) J Immunol. 163: 2151-2159.
Meinke A, et al. (1996) Mol Cell Biol. 16: 6937-6944.

如果您使用该产品11048发表了文章,请通知我们,让我们可以引用您的文献。

et al,A thiazole-derived oridonIn analogue exhibits antitumor activity by directly and allosterically InhibitIng STAT3. In J Biol Chem on 2019 Nov 15;by Shen X, Zhao L,et al..PMID:31594861, , (2019),
PMID: 31594861
et al, The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFR伪 and PDGFR伪 D842V.In Mol Oncol on 2014 May by Laura A No毛l , Florence A Arts et al..PMID:24618081, , (2016),
PMID: 24618081
et al,JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.In Leukemia on 2014 Feb by A Bouchekioua 1 , L Scourzic et al..PMID: 23689514, , (2014),
PMID: 23689514
et al, PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations.In Oncogene on 2014 May 15 by A I Velghe, S Van Cauwenberghe et al..PMID:23752188 , , (2014),
PMID: 23752188
Drechsler J, Gro隆搂 tzinger J, Hermanns HM et al,Characterization of the Rat Oncostatin M Receptor Complex Which Resembles the Human, but Differs from the Murine Cytokine Receptor. , PLoS ONE, 7(8): e43155. (2012),
PMID: 22937020
et al,Downregulation of CCND1 and CDK6 by miR-34a Induces Cell Cycle Arrest.In FEBS Lett on 2008 Apr 30 by Fang Sun, Hanjiang Fu,et al..PMID:18406353, , (2008),
PMID: 18406353
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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