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dynactin 1 antibody#22058

dynactin 1 antibody
dynactin 1 antibody
dynactin 1 antibody
是否有货: 有货
产品总价:
产品详情

产品名称dynactin 1 antibody

来源种属Rabbit

克隆性Polyclonal

纯化Purified by antigen-affinity chromatography.

应用WB IHC IF

种属反应性Hu

免疫原类型Peptide

免疫原描述Synthetic peptide contain a sequence corresponding to a region within amino acids 1216 and 1278 of dynactin 1

基因/蛋白名称dynactin 1

数据库入口号NCBI Gene ID: 1639
NCBI mRNA#: NM_004082
NCBI Protein#: NP_004073

浓度1mg/ml

配方Supplied in 1XPBS, 1%BSA, 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

保存Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.

应用详情

Predicted MW: 142kd
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:250
Immunofluorescence: 1:100-1:200

Sample (30 ug of whole cell lysate)
A: JurKat
5% SDS PAGE
Primary antibody diluted at 1: 3000
Immunohistochemical analysis of paraffin-embedded OVCA, using dynactin 1 antibody at 1: 100 dilution.
Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using DCTN1 antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 2000.
背景

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq]

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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