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位置: 首页 > 磷酸化抗体 > p95/NBS1(Phospho-Ser343) Antibody

p95/NBS1(Phospho-Ser343) Antibody#11057

p95/NBS1(Phospho-Ser343) Antibody
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产品总价:
产品详情

产品名称p95/NBS1(Phospho-Ser343) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu

特异性The antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 343 (S-L-S(p)-Q-G) derived from Human p95/NBS1.

基因/蛋白名称p95/NBS1

修饰Phospho

别名NBN

数据库入口号Swiss-Prot: O60934
NCBI Protein: NP_002476.2

UniprotO60934

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 95kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Hela cells untreated or treated with Hydroxyurea using p95/NBS1(Phospho-Ser343) Antibody #11057.
背景
Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Hsu HL, et al (2005) Oncogene; 24(31): 4956-64.
Falck J, et al. (2005) Nature; 434(7033): 605-11.
Buscemi G, et al. (2004) Oncogene; 23(46): 7691-700.
Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101(33): 12130-5.

如果您使用该产品11057发表了文章,请通知我们,让我们可以引用您的文献。

et al,Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D.In J Exp Clin Cancer Res. On 2018 Nov 27 by Qiang Z, Zhou ZY et al..PMID: 30482227, , (2018),
PMID: 30482227
Rachid Drissi, Jing Wu, Yafang Hu et al,Telomere Shortening Alters the Kinetics of the DNA Damage Response after Ionizing Radiation in Human Cells, Cancer Prevention Research, 4(12):1973篓C1981 (2011),
PMID: 21930799
et al,Telomere Shortening Alters the Kinetics of the DNA Damage Response After Ionizing Radiation in Human Cells.In Cancer Prev Res (Phila) on 2011 Dec by Rachid Drissi, Jing Wu, et al..PMID:21930799, , (2011),
PMID: 21930799
F Carrillo, SA Schneider, AMR Taylor et al,Prominent Oromandibular Dystonia and Pharyngeal Telangiectasia in Atypical Ataxia Telangiectasia. , Cerebellum, 8:22篓C27 (2009),
PMID: 18846412
et al,Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia.In Cerebellum on 2009 Mar by Carrillo F,Schneider SA,et al..PMID:18846412, , (2009),
PMID: 18846412
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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