产品详情
产品名称VEGFR2(Phospho-Tyr1175) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用IHC IF
种属反应性Human;Mouse;Rat
特异性The Antibody detects endogenous level of VEGFR2 only when phosphorylated at tyrosine 1175.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of tyrosine 1175 (K-D-Y(p)-I-V) derived from Human VEGFR2.
基因/蛋白名称VEGFR2
标记Unconjugated
别名FLK1; KDR; VGFR2; VGR2; kinase insert domain receptor
数据库入口号Swiss-Prot: P35968
NCBI Protein: NP_002244.1
Uniprot
P35968
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 230kd
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using VEGFR2(Phospho-Tyr1175) Antibody #11084(left) or the same antibody preincubated with blocking peptide(right).
Immunofluorescence staining of methanol-fixed MCF cells using VEGFR2(Phospho-Tyr1175) Antibody #11084.
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Lamalice L, et al. (2004). Oncogene.23(2): 434-445.
Takahashi T, et al. (2001). EMBO J .20(11): 2768-2778.
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et al,Endogenous acetylcholine regulates neuronal and astrocytic vascular endothelial growth factor expression levels via different acetylcholine receptor mechanisms.In Neurochem Int. On 2018 Sep by Kimura K, Matsumoto K et al..PMID: 29705288
, (2018),
PMID:
29705288
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