产品详情
产品名称TrkB(Phospho-Tyr515) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB;IHC;IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 515.
免疫原类型Peptide
免疫原描述The antiserum was produced against synthesized peptide derived from human Trk B around the phosphorylation site of Tyr515.
基因/蛋白名称TrkB
标记Unconjugated
别名BDNF/NT-3 growth factors receptor precursor; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; Trk-B
数据库入口号Swiss-Prot: Q16620
NCBI Protein: NP_001007098.1
Uniprot
Q16620
实际分子量145kDa or 92kDa
浓度1.0mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
WB 1:500-1:2000;
IHC 1:100-1:300;
IF 1:50-1:200
Western Blot analysis of RAT-MUSCLE cells using TrkB(Phospho-Tyr515) Antibody diluted at 1:1000.
Immunohistochemistry analysis of paraffin-embedded human brain, using TrkB(Phospho-Tyr515) Antibody. The picture on the right is blocked with the phospho peptide.
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.
Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.
Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.
Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.
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