产品详情
产品名称SH-PTP1 (phospho-Tyr564) Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB,ELISA
种属反应性Human;Monkey
特异性Phospho-SH-PTP1 (Y564) Polyclonal Antibody detects endogenous levels of SH-PTP1 protein only when phosphorylated at Y564.
免疫原描述The antiserum was produced against synthesized peptide derived from human SHP-1 around the phosphorylation site of Tyr564. AA range:530-579
标记Unconjugated
别名PTPN6; HCP; PTP1C; Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
数据库入口号Swiss Prot:P29350
GeneID:5777
Uniprot
P29350
实际分子量70
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
Western Blot: 1/500 - 1/2000.
ELISA: 1/5000. Not yet tested in other applications.
protein tyrosine phosphatase, non-receptor type 6(PTPN6) Homo sapiens The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul
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et al,ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth
, (2025),
PMID:
39824978
Yes
