产品详情
产品名称MYPT1 (phospho-Ser668) rabbit pAb
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
应用WB
种属反应性Human
特异性This antibody detects endogenous levels of Human MYPT1 (phospho-Ser668)
免疫原描述Synthesized phosho peptide around human MYPT1 (Ser668)
标记Unconjugated
别名Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
数据库入口号Swiss Prot:O14974
GeneID:4659
Uniprot
O14974
实际分子量130
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
WB 1:1000-2000
protein phosphatase 1 regulatory subunit 12A(PPP1R12A) Homo sapiens Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosph
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et al,Saikosaponin D ameliorates sepsis-induced acute lung injury by maintaining alveolar epithelial barrier integrity and inhibiting ferroptosis via Nrf2/HO-1 pathway
, (2025),
PMID:
40569790
Yes
