产品详情
产品名称MEK-1/2 (phospho-Ser222/226) Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB,IHC-p,IF(paraffin section),ELISA
种属反应性Human;Mouse;Rat
特异性Phospho-MEK-1/2 (S222/226) Polyclonal Antibody detects endogenous levels of MEK-1/2 protein only when phosphorylated at S222/226.
免疫原描述The antiserum was produced against synthesized peptide derived from human MEK1/2 around the phosphorylation site of Ser221. AA range:193-242
标记Unconjugated
别名MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k
数据库入口号Swiss Prot:Q02750/P36507
GeneID:5604/5605
Uniprot
Q02750
实际分子量44
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
Western Blot: 1/500 - 1/2000.
Immunohistochemistry: 1/100 - 1/300.
ELISA: 1/20000. Not yet tested in other applications.
mitogen-activated protein kinase kinase 1(MAP2K1) Homo sapiens The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008],
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et al,GDF15 alleviates the severity of experimental autoimmune myocarditis by inhibiting B cells function
, (2025),
PMID:
41232385
Yes
