产品详情
产品名称HER2/ErbB2 (phospho-Tyr1196) rabbit pAb
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
应用WB
种属反应性Human;Mouse
特异性This antibody detects endogenous levels of Human Mouse HER2/ErbB2 (phospho-Tyr1196)
免疫原描述Synthesized phosho peptide around human HER2 and ErbB2 (Tyr1196)
标记Unconjugated
别名Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
数据库入口号Swiss Prot:P04626
GeneID:2064
Uniprot
P04626
实际分子量180
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
WB 1:1000-2000
erb-b2 receptor tyrosine kinase 2(ERBB2) Homo sapiens This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d
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et al,Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models
, (2025),
PMID:
40171975
Yes
