产品详情
产品名称Catenin-β (phospho-Tyr489) Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB;IHC;IF;ELISA
种属反应性Human;Mouse;Rat;Monkey
特异性Phospho-Catenin-β (Y489) Polyclonal Antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Y489.
免疫原描述The antiserum was produced against synthesized peptide derived from human Catenin-beta around the phosphorylation site of Tyr489. AA range:455-504
基因/蛋白名称Catenin-β
标记Unconjugated
别名CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
数据库入口号Swiss Prot:P35222
GeneID:1499
Uniprot
P35222
实际分子量85
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
catenin beta 1(CTNNB1) Homo sapiens The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],
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et al,High‐Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice
, (2025),
PMID:
41328591
Yes
