产品详情
产品名称ASK1 (phospho-Thr845) rabbit pAb
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
应用WB
种属反应性Human
特异性This antibody detects endogenous levels of Human ASK1 (phospho-Thr845)
免疫原描述Synthesized phosho peptide around human ASK1 (Thr845)
标记Unconjugated
别名Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
数据库入口号Swiss Prot:Q99683
GeneID:4217
Uniprot
Q99683
实际分子量155
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
WB 1:1000-2000
mitogen-activated protein kinase kinase kinase 5(MAP3K5) Homo sapiens Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by Re
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et al,ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
, (2025),
PMID:
39561764
Yes
