产品详情
产品名称Cortactin Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous level of total Cortactin protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.419~423 (P-I-Y-E-D) derived from Human CORTACTIN.
基因/蛋白名称Cortactin
标记Unconjugated
别名Amplaxin; CTTN; EMS1; SRC8;
数据库入口号Swiss-Prot: Q14247
NCBI Protein: NP_005222.2
Uniprot
Q14247
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 85kd
Immunohistochemistry: 1:50~1:100
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cortactin(Ab-421) Antibody #21263(left) or the same antibody preincubated with blocking peptide(right).
Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Luo C, et al. (2006) J Biol Chem ; 281(40):30081-30093
Head JA, et al. (2003) Mol Biol Cell ;14(8):3216-3229
Salomon AR, et al. (2003) PNAS ; 100(2): 443-448
Huang C, et al. (1998) J Biol Chem ; 273(40): 25770-25776.
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et al,analysis: an analysis based on the European spontaneous adverse event reporting system
, (2025),
PMID:
39877384
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