产品详情
产品名称BIM Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total BIM protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.67~71 (P-A-S-P-G) derived from Human BIM.
基因/蛋白名称BIM
标记Unconjugated
别名BCL2-like protein 11; BCL2L11; BOD; Bcl-2 related ovarian death protein;
数据库入口号Swiss-Prot: O43521
NCBI Protein: NP_006529.1
Uniprot
O43521
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 23kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from Hela cells using BIM(Ab-69) Antibody #21280.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BIM(Ab-69) Antibody #21280(left) or the same antibody preincubated with blocking peptide(right).
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
Fukazawa H, et al. (2004) Mol Cancer Ther ; 3(10): 1281-1288
Luciano F, et al. (2003) Oncogene ; 22(43): 6785-6793
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et al,Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.In Biomed Pharmacother on 2016 Dec by Fengxia Yan , Rifang Liao et al..PMID: 27881235
, (2016),
PMID:
27881235
et al,The antisense lncRNA of TAB2 that prevents oxidative stress to enhance the follicular growth in mammals. In Commun Biol
on 2024 Oct 2 by Nian Li, Bing Yun,et al..PMID:39358475
, (2024),
PMID:
39358475
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