产品详情
产品名称RASSF1 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Purified by antigen-affinity chromatography.
应用WB IF
种属反应性Human
免疫原类型Recombinant protein
免疫原描述Recombinant protein fragment contain a sequence corresponding to a region within amino acids 50 and 334 of RASSF1
基因/蛋白名称RASSF1
标记Unconjugated
数据库入口号NCBI Gene ID: 11186
NCBI mRNA#: NM_170714
NCBI Protein#: NP_733832
浓度1mg/ml
配方Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
保存Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
应用详情
Predicted MW: 39kd
Western blotting: 1:500-1:3000
Immunofluorescence: 1:100-1:200
Sample(30 ug whole cell lysate)
A: 293T
12% SDS PAGE
Primary antibody diluted at 1: 500
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using RASSF1 antibody at 1: 100 dilution.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
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et al,IRF7 in peripheral monocytes drives BBB disruption in anti-NMDAR encephalitis
, (2025),
PMID:
40738265
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