产品详情
产品名称NAIP Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB ICC
种属反应性Human
特异性Minor, lower molecular weight bands may represent alternately spliced forms.
免疫原类型Peptide
免疫原描述Raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.
基因/蛋白名称NAIP
标记Unconjugated
数据库入口号AAC52047
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Immunocytochemistry of NAIP in A549 cells with NAIP antibody at 10 ug/mL.
Western blot analysis of NAIP in human tonsil tissue lysate with NAIP antibody at 1 μg/mL.
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
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et al,[HTML][HTML] Structure-Affinity Driven Repurposing of Natural Compounds and Herbal Prescriptions for Ulcerative Colitis and Psoriasis
, (2025),
PMID:
40582205
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