产品详情
产品名称TEM5 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Rat
免疫原类型Peptide
免疫原描述Raised against a 14 amino acid peptide near the center of human TEM5.
基因/蛋白名称TEM5
标记Unconjugated
别名Tumor endothelial marker 5, G protein-coupled receptor 124, GPR124
数据库入口号Q96PE1
Uniprot
Q96PE1
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of TEM5 in rat kidney tissue lysate with TEM5 antibody at (A) 2 ug/ml and (B) 4 ug/mL.
Immunohistochemistry of TEM5 in human bladder tissue with TEM5 antibody at 5 ug/mL.
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
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et al,Multifunctional Inorganic-Nanosheets-Based Nanohydrogel for Periodontal Bone Regeneration via Antibacterial and Anti-Ferroptotic Immunomodulation
, (2025),
PMID:
41250788
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