产品详情
产品名称Grik1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide near the carboxy terminus of the human Grik1.
基因/蛋白名称Grik1
标记Unconjugated
别名Glutamate receptor ionotropic kainate 1, glutamate receptor 5, gluR5, excitatory amino acid receptor 3, eea3
数据库入口号P39086
Uniprot
P39086
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Grik1 in P815 cell lysate with Grik1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunohistochemical staining of human brain tissue using Grik1 antibody at 2.5 ug/mL.
Immunofluorescence of Grik1 in mouse brain tissue with Grik1 Antibodyat 20 μg/mL.
Immunohistochemistry of Grik1 in mouse brain tissue with Grik1 Antibodyat 5 μg/mL.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
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et al,PFGA12 ameliorates Hypoxic-Ischemic brain injury by directly regulating PRDX1 and inhibiting ferroptosis
, (2025),
PMID:
40921222
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