产品详情
产品名称Prosapip1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 16 amino acid peptide from near the carboxy terminus of human Prosapip1.
基因/蛋白名称Prosapip1
标记Unconjugated
别名Proline-rich synapse-associated protein-interacting protein 1
数据库入口号NP_055546
Uniprot
NP_055546
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Prosapip1 in SK-N-SH cell lysate with Prosapip1 antibody at 1 ug/mL.
Immunohistochemistry of Prosapip1 in rat brain tissue with Prosapip1 antibody at 2.5 ug/mL.
Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3’s PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins’. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.
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et al,Sensory neuron TRPV1-mediated macrophage polarization and immune response regulate dental implant osseointegration
, (2025),
PMID:
41297248
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