产品详情
产品名称Lin28 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide near the carboxy terminus of human Lin28.
基因/蛋白名称Lin28
标记Unconjugated
别名Lin28A, CSDD1, ZCCH1
数据库入口号EAX07814
Uniprot
EAX07814
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Lin28 in Raji cell lysate with Lin28 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of KLF4 in human spleen tissue with KLF4 antibody at 5 ug/mL.
Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
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et al,Geniposide activates the NLRP3 inflammasome pathway to induce nephrotoxicity by regulating FXR/PERK/TXNIP pathways
, (2025),
PMID:
41260456
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