产品详情
产品名称BCAS4 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 14 amino acid peptide near the amino terminus of human BCAS4.
基因/蛋白名称BCAS4
标记Unconjugated
别名Breast carcinoma amplified sequence 4, CNOL
数据库入口号CAI23006
Uniprot
CAI23006
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of BCAS4 in 3T3 cell lysate with BCAS4 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of BCAS4 in human breast carcinoma with BCAS4 antibody at 5 ug/mL.
The Breast carcinoma amplified sequence (BCAS4) gene is localized to 20q13, a region that is often amplified in breast cancers. It was isolated by the cloning of a highly overexpressed 1.3 kb transcript from the fusion of the last two exons of the BCAS3 and BCAS4 genes. This BCAS3-BCAS4 fusion transcript is only found in the MCF7 cell line, but the BCAS4 gene is also overexpressed in nine of thirteen breast cancer cell lines. The role of BCAS4 is unknown but its mRNA is highly expressed in thymus, spleen, kidney, brain, and placenta, suggesting BCAS4 plays other roles in multiple tissues.
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et al,Activation of bitter taste receptor TAS2R4 alleviates diabetic nephropathy in mice
, (2025),
PMID:
40228633
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