产品详情
产品名称NALP7 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human
免疫原类型Peptide
免疫原描述Raised against an 18 amino acid peptide near the amino terminus of human NALP7.
基因/蛋白名称NALP7
标记Unconjugated
别名NLR family pyrin domain containing 7, NLRP7, PYRIN-containing APAF1-like protein 3, PYPAF3, NOD12, CLR19.4, PAN7, HYDM
数据库入口号NP_631915
Uniprot
NP_631915
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 ug/mL.
NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
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et al,GPCPD1 is regulated by METTL3/IGF2BP3 dependent m6A modification to affect pig muscle fiber type conversion
, (2025),
PMID:
40404071
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