产品详情
产品名称PUMA Monoclonal Antibody
克隆号mAb (Clone 2A8F6)
来源种属Mouse
克隆性Monoclonal
纯化Immunoaffinity chromotography purified IgG
应用ELISA WB
种属反应性Human;Rat
免疫原类型Recombinant protein
免疫原描述Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
基因/蛋白名称PUMA
标记Unconjugated
别名PUMA (2A8F6), p53 upregulated modulator of apoptosis, bbc3, Bcl-2 binding component 3
数据库入口号Q9BXH1
Uniprot
Q9BXH1
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year.
应用详情
Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/mL.
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
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et al,MAPK1 regulates platelet function and thrombus formation
, (2025),
PMID:
40447106
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