产品详情
产品名称IRAK Monoclonal Antibody
克隆号mAb (Clone 1F12C1)
来源种属Mouse
克隆性Monoclonal
纯化Immunoaffinity chromotography purified IgG
应用ELISA WB IHC
种属反应性Human;Mouse
免疫原类型Recombinant protein
免疫原描述Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
基因/蛋白名称IRAK
标记Unconjugated
别名IRAK (1F12C1),IL-1-Receptor Associated Kinase
Uniprot
P51617
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year.
应用详情
Western blot analysis of IRAK in HeLa lysates with IRAK antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of IRAK in rat liver tissue with IRAK antibody at 2.5 ug/mL.
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
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