产品详情
产品名称KLF4 Monoclonal Antibody
克隆号mAb (Clone 4E5C3)
来源种属Mouse
克隆性Monoclonal
纯化KLF4 Monoclonal Antibody is Protein A purified.
应用ELISA WB
种属反应性Human;Mouse;Rat
特异性At least three isoforms of KLF4 are known to exist; this antibody will detect all three. KLF4 antibody will not cross-react with other Kruppel-like family members.
免疫原类型Peptide
免疫原描述Raised against a 20 amino acid peptide near the carboxy terminus of human KLF4.
基因/蛋白名称KLF4
标记Unconjugated
别名Kruppel-like factor 4, GKLF, EZF
数据库入口号AAH30811
Uniprot
AAH30811
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year.
应用详情
Western blot analysis of KLF4 in mouse liver tissue lysate with KLF4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.
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et al,Moxibustion Enhances Ovarian Function by Inhibiting the Th17/IL‐17 Pathway and Regulating Gut Microbiota in POI Rats
, (2025),
PMID:
40322835
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