产品详情
产品名称COL1A1 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human COL1A1 (NP_000079.2).
标记Unconjugated
别名COL1A1; EDSC; OI1; OI2; OI3; OI4; collagen alpha-1(I) chain
数据库入口号Swiss-Prot#:P02452
NCBI Gene ID:1277
Uniprot
P02452
计算分子量139kDa
实际分子量130-160 kDa,210-250kDa
配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
保存Store at -20˚C
应用详情
WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using COL1A1 antibody.
Immunohistochemistry of paraffin-embedded human colon carcinoma using COL1A1 antibody.
Immunohistochemistry of paraffin-embedded human placenta using COL1A1 antibody.
Immunohistochemistry of paraffin-embedded rat ovary using COL1A1 antibody.
Immunofluorescence analysis of rat ovary using COL1A1 antibody.
Immunofluorescence analysis of human breast cancer using COL1A1 antibody.
Immunofluorescence analysis of human breast cancer using COL1A1 antibody.
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
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Yes
