产品详情
产品名称CYP11A1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB IHC IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total CYP11A1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human CYP11A1.
基因/蛋白名称CYP11A1
标记Unconjugated
别名CYP11A; CYPXIA1; P450SCC;
数据库入口号Swiss-Prot:P05108
NCBI Gene ID:1583
Uniprot
P05108
实际分子量60KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using CYP11A1 antibody.
Immunofluorescence analysis of MCF7 cell using CYP11A1 antibody. Blue: DAPI for nuclear staining.
The formation of biologically active steroid hormones is significantly influenced by the motrochondrial cytochrome P450 enzyme, chrolesterol side-chain cleavage. CYP11A1 functions in catalyzing the first step of steroid biosynthesis under modulation of cAMP.It ia also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA. Expression of CYP11A1 has been a useful tool for monitoring the differentiation state of cells from varius endocrine tissues. Identification of CYP11A1 expression by 13363-1-AP detected a ~45kd band in human placenta, with respect to the reported band at 49-52kd by Roby, et al and Durkee, et al.
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et al,Multi-omics atlas of ovarian cellular and molecular responses to diabetes
, (2025),
PMID:
41397560
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