产品详情
产品名称NR1I3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total NR1I3 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human NR1I3.
基因/蛋白名称NR1I3
标记Unconjugated
别名CAR; CAR1; MB67;
数据库入口号Swiss-Prot:Q14994
NCBI Gene ID:9970
Uniprot
Q14994
实际分子量39KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using NR1I3 antibody at 1:1000 dilution.
Immunofluorescence analysis of U2OS cells using NR1I3 antibody. Blue: DAPI for nuclear staining.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene
如果您使用该产品32527发表了文章，请通知我们，让我们可以引用您的文献。
et al,Sea buckthorn regulates PXR/CAR/NF-κB signaling and restores CYP2C metabolic function in BCG-induced hepatitis
, (2025),
PMID:
40513919
有货
