产品详情
产品名称HTR3A Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total HTR3A protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human HTR3A (NP_000860.2).
基因/蛋白名称HTR3A
标记Unconjugated
别名HTR3A;5-HT-3;5-HT3A;5-HT3R;5HT3R;HTR3
数据库入口号Uniprot:P46098
GeneID:3359
Uniprot
P46098
Gene ID
3359
实际分子量55kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using HTR3A antibody.
Immunohistochemistry of paraffin-embedded rat brain using HTR3A antibody.
Immunohistochemistry of paraffin-embedded mouse brain using HTR3A antibody.
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
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et al,Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration
, (2025),
PMID:
41190020
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