产品详情
产品名称p18 INK Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total p18 INK protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human p18 INK antibody.
基因/蛋白名称p18 INK
标记Unconjugated
别名OTTHUMP00000046546; p18(INK4C); p18-INK4C; CDK6 inhibitor p18; cyclin-dependent inhibitor
数据库入口号Swiss-Prot: P42773
NCBI Gene ID: 1031
Uniprot
P42773
实际分子量18kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from COS7 cells, using p18 INK antibody #33458.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p18 INK antibody #33458.
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Youzhong Yuan, Cancer Res., Jan 2006; 66: 343 - 351.
A. Koenig, Vet. Pathol., Jul 2002; 39: 458.
Pei-Fang Hung, Am J Physiol Cell Physiol, May 2005; 288: C1094 - C1108.
Mana Mirjany, J. Pharmacol. Exp. Ther., May 2002; 301: 494.
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et al,analysis: an analysis based on the European spontaneous adverse event reporting system
, (2025),
PMID:
39877384
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