产品详情
产品名称PAK7 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Rat
特异性The antibody detects endogenous levels of total PAK7 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from C-terminal of human PAK7.
基因/蛋白名称PAK7
标记Unconjugated
别名KIAA1264; p21-activated kinase 7; PAK 7; PAK-5; PAK-7
数据库入口号Swiss-Prot: Q9P286
NCBI Gene ID: 57144
Uniprot
Q9P286
实际分子量80kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from rat brain cells, using PAK7 antibody #35292.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PAK7 antibody #35292.
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Pandey A., Oncogene 21:3939-3948(2002).
Nagase T., DNA Res. 6:337-345(1999).
Deloukas P., Nature 414:865-871(2001).
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et al,ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth
, (2025),
PMID:
39824978
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