产品详情
产品名称TLR4 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by antigen-affinity chromatography.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total TLR4 protein.
免疫原类型Recombinant Protein
免疫原描述A synthesized peptide derived from human TLR4
基因/蛋白名称TLR4
标记Unconjugated
别名ARMD10 antibody; CD284 antibody; TOLL antibody; hToll antibody; TLR4 antibody; homolog of Drosophila toll antibody; toll-like receptor 4 antibody
数据库入口号Swiss-Prot#:O00206;
NCBI Gene#:7099
Uniprot
O00206
实际分子量96kd
浓度1mg/ml
配方Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunofluorescence: 1:50-1:200
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq]
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